吃了这么久降糖药，为什么血糖还是反复？

After taking diabetes medications for so long, why does my blood sugar still keep fluctuating?

背景

不少糖友都有类似的纳闷：药一直按时吃，饭也不敢放开了造，可血糖仪上的数字还是上蹿下跳，有时候比刚查出来那会儿还难伺候。其实血糖反复不等于药白吃了，更像是几股力量在同时较劲。

Many people with diabetes share this puzzle: they take their medication on schedule and don’t even dare to indulge in their diet, yet the numbers on the glucometer still bounce up and down — sometimes even more unruly than when they were first diagnosed. In fact, fluctuating blood sugar doesn’t mean the medication is wasted; it’s more like several forces pulling against each other at the same time.

隐形升糖

最容易被忽略的是饮食里的”隐形升糖”。很多人觉得自己没碰甜食，却忘了白粥、白米饭、馒头这些主食下肚有多快。一碗热粥喝完，血糖冲得可能比一块蛋糕还猛。再加上油炸、重口味、半夜加餐，药物刚压下去的数值，又被吃法悄悄顶了回来。

The most easily overlooked factor is the “hidden sugar spikes” in the diet. Many people think they haven’t touched anything sweet, but forget how quickly staple foods like plain congee, white rice, and steamed buns turn into sugar in the body. A bowl of hot congee can send blood sugar soaring even more sharply than a slice of cake. Add in fried foods, heavily seasoned dishes, and late-night snacks, and the numbers the medication just brought down get quietly pushed back up by eating habits.

运动欠账

运动这头也常常欠账。肌肉是消耗血糖的主力，长期坐着不动，身体对胰岛素就越来越”不给面子”。有些人吃完药就瘫在沙发上，等于只给药、不给出口，糖分自然全堆在血里。

Exercise is another area where people often fall short. Muscles are the main consumers of blood sugar. Sitting still for long periods makes the body increasingly “unresponsive” to insulin. Some people collapse on the couch right after taking their meds — it’s like giving the drug but providing no outlet, so the sugar just piles up in the blood.

睡眠与压力

还有睡眠和压力这两个”暗手”。熬夜、焦虑会逼身体分泌升糖激素，这时候再好的药也得顶着风干活。不少人的血糖波动，根子不在碗里，而在枕头边上。

Then there are the two “hidden hands”: sleep and stress. Staying up late and anxiety force the body to secrete sugar-raising hormones, so even the best medication has to work against the wind. For many people, the root of blood sugar swings isn’t in the bowl, but by the pillow.

间充质干细胞

聊到这，就绕不开一个越来越多人在问的方向：间充质干细胞。它在 2 型糖尿病上的思路和传统降糖药不太一样。传统降糖药大多是”催”——催着胰腺多产胰岛素，或者逼着细胞多吸糖。间充质干细胞更像是”修”。它能分泌一堆修复因子，帮胰岛改善周围的微环境，让还剩口气的胰岛细胞少受炎症折磨，慢慢喘口气、恢复点功能。

This brings us to a direction more and more people are asking about: mesenchymal stem cells (MSCs). Their approach to type 2 diabetes differs from traditional hypoglycemic drugs. Most traditional drugs “push” — pushing the pancreas to produce more insulin, or forcing cells to absorb more sugar. MSCs are more like “repair.” They secrete a host of repair factors that help improve the microenvironment around the islets, sparing the still-functioning islet cells from inflammatory damage, letting them catch their breath and gradually regain some function.

它的另一个看点是免疫调节。2 型糖尿病背后其实压着一层慢性炎症，干细胞能帮着把这股异常的免疫攻击压一压，从根上给胰岛减减负。更关键的是，它盯着的是”胰岛素抵抗”这个老难题。很多糖友不是缺胰岛素，而是身体用不动它。干细胞辅助提升组织对胰岛素的敏感度，等于把堵死的门重新推开。

Another highlight is immune regulation. Behind type 2 diabetes lies a layer of chronic inflammation; stem cells can help suppress this abnormal immune attack, easing the burden on the islets at the root. More importantly, they target the old nemesis of “insulin resistance.” Many diabetics don’t lack insulin — their bodies just can’t use it properly. Stem cells help boost tissue sensitivity to insulin, like pushing open a jammed door again.

当然，干细胞不是神药，也替代不了规范用药和吃饭运动这些基本功。它更像一个补位选手，给那些血糖长期压不住、并发症苗头开始冒头的人，多递一种选择。真要考虑，也得走正规医疗机构、有合规临床方案的路子。

Of course, stem cells are no miracle cure, and they can’t replace the fundamentals: proper medication, diet, and exercise. They are more like a substitute player, offering another option for those whose blood sugar stays uncontrolled long-term and whose complications are starting to emerge. If you really want to consider it, you must go through proper medical institutions with compliant clinical protocols.

机构与合规

广州达博生物相关干细胞治疗技术，已在北戴河生命健康产业创新示范区，依托国家”先行先试”政策开展合规转化应用；所有项目均在合规医疗机构、由执业医生评估、知情同意下规范开展，严格遵循相关备案与监管要求。

The stem cell therapy technology of Guangzhou Doublle Biology has been carried out as a compliant translational application in the Beidaihe Life Health Industry Innovation Demonstration Zone, relying on the national “pilot and trial” policy. All projects are conducted in compliance at licensed medical institutions, assessed by licensed physicians, and carried out under informed consent, strictly following relevant filing and regulatory requirements.

北戴河生命健康产业创新示范区作为国家级健康产业先行先试区，始终聚焦前沿创新医疗技术的引进和转化，配套绿色通道和加速审批机制，实现区内先行先试，加速技术成熟，解决临床痛点。本次获批的项目，技术先进、工艺和质量管理体系成熟、有亟待满足的迫切临床需求，和先行先试政策高度互补。但这绝不意味着”放松监管”——恰恰相反，参与转化的医疗机构须完成备案、方案须经伦理审查、实施须取得患者知情同意、全程可追溯。

As a national-level pilot zone for the health industry, the Beidaihe Life Health Industry Innovation Demonstration Zone has always focused on introducing and translating cutting-edge innovative medical technologies, with supporting green channels and accelerated approval mechanisms, enabling pilot implementation within the zone, accelerating technology maturity, and addressing clinical pain points. The newly approved project features advanced technology, mature processes and quality management systems, and urgent unmet clinical needs, making it highly complementary to the pilot policy. But this absolutely does not mean “loosening oversight” — on the contrary, medical institutions involved in translation must complete filing, protocols must pass ethical review, implementation must obtain patient informed consent, and the entire process must be traceable.

咨询通道

如您或家人希望了解是否适合参与生物医学新技术临床研究和临床转化应用，欢迎添加微信：（备注”细胞治疗咨询”，由专业团队对接合规咨询）

If you or your family would like to know whether you are suitable to participate in clinical research and clinical translation applications of new biomedical technologies, feel free to add our WeChat: (note “cell therapy consultation” in the request, and a professional team will connect you for compliant consultation).